Dr. Tang mainly uses the technical means of medicinal chemistry and chemical biology to discover active molecules and apply them to basic research in chemical biology and innovative drug discovery. His current research interests include: 1) drug discovery and development for diseases such as respiratory diseases and malignant tumors; 2) design, synthesis and application of bioactive tool molecules for study of protein-protein interaction; 3) synthetic strategy and process optimization of small molecule drugs.
1. A fluorosulfonic acid compound and its application, application number: 2024105555109, application date: May 7, 2024, inventors: Bing Yang, Shibing Tang, Dandan Liu.
2. Bicyclic compounds, their drug compositions and their uses, application number: 2024104035592, application date: April 3, 2024, inventors: Shibing Tang, Xiangqian Kong, Cheng Luo, Kehao Zhao, Zhihai Li, Jian Chen, Yufang Shi, Yong Zhang, Yazhou Wang.
3. A small molecule chemical crosslinker and preparation method and application thereof, application number: 202310163905X, patent number: 202310163905.X, authorization date: May 17, 2024, Inventor: Shibing Tang, Bing Yang, Ting Wu.
4. DNMT1 inhibitors, pharmaceutical compositions, and therapeutic applications, application number: PCT/CN2024/074266, application date: January 26, 2024, inventors: Shibing Tang, Xiangqian Kong, Cheng Luo, Kehao Zhao, Zhihai Li, Jian Chen, Yufang Shi, Yong Zhang.
5. A bifunctional immunomodulator and its pharmaceutically acceptable salt and drug composition, application number: PCT/CN2020/094580, authorized number: 202080018398.5, authorization date: May 10, 2022, inventors: Shibing Tang, Shaogao Zeng, Micky Daniel. Tortorella.
6. Photoreceptor gene modulator photoregulin 3 for treatment of retinal disease, application date: PCT/US2018/046272 (WO2019032999), application date: August 10, 2018, inventors: Thomas A. Reh, Paul Nakamura, Andy Shimchuk, Shibing Tang, Sheng Ding.
1.Liu DD#, Ding W#, Cheng JT#, Wei Q#, Lin Y, Zhu TY, Tian J, Sun K, Zhang L, Lu P, Yang F, Liu C*, Tang S*, Yang B*. Characterize direct protein interactions with enrichable, cleavable and latent bioreactive unnatural amino acids. Nat Commun. 2024 Jun 18;15(1):5221. PMID: 38890329. (#equal contribution)
2.Xu Y#, Liu J#, Li G, Wu H, Du X, Ma T, Liu D, Tang S*.Efficient synthesis of 1-Azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration. New J Chem. 2024 Jun 18;48:12081-12085. (#equal contribution)
3.Zhu C, Liu J, Ni Y, Chen W, Rong W, Zhang X, Guo C, Kong X*, Tang S*. Synthesis of STM2457, a selective small-molecule inhibitor of METTL3. Tetrahedron lett. 2024 May 17;141: 155077.
4.Tian J, Lin Y, Han J*, Tang S*. Practical synthesis of epocholeone, a plant growth-promoting steroid with long-lasting activity. Tetrahedron lett. 2024 Apr 28;140: 155024.
5.Wu T#, Li ST#, Ran Y#, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B*, Tang S*. Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells. Redox Biol. 2023 May;61:102642. PMID: 36863169 (#equal contribution)
6.Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X. SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation. Cell Biosci. 2021 Jul 27;11(1):146. PMID: 34315543
7.Liu X, Zhang Y, Chu Y, Zhao X, Mao L, Zhao S, Lin S, Hui X, Gu P, Xu Y, Loomes K, Tang S*, Nie T*, Wu D*. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. Biochem Biophys Res Commun. 2021;545:189-194. PMID: 33561654
8.Tan J, Liu H, Huang M, Li N, Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Cell Death Dis. 2020 Aug 22;11(8):697. PMID: 32829384
9.Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T.Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sci. 2019 Apr 1;222:117-124. PMID: 30708100
10.Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S, Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T. Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway. Mol Metab. 2019 Oct;28:48-57. PMID: 31352005
11.Hou L#, Yang G#, Tang S#, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF. A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease. J Am Heart Assoc. 2018 Sep 18;7(18):e009234. PMID: 30371212 (#equal contribution)
12.Qin Y#, Tang S#, Zhen G, Ding Q, Ding S, Cao X. Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease. Ann N Y Acad Sci. 2018 Dec; 1433(1):29-40. PMID: 30091466 (#equal contribution)
13.Yang B#, Tang S#, Ma C#, Li ST, Shang GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 Dec 21;8(1):2240. PMID: 29269770 (#equal contribution)
14.Xie M#, Tang S#, Li K, Ding S. Pharmacological reprogramming of somatic cells for regenerative medicine. Acc Chem Res. 2017 May 16; 50(5):1202-1211. PMID: 28453285. (#equal contribution)
15.Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical enhancement of in vitro and in vivo direct cardiac reprogramming. Circulation. 2017 Mar 7; 135(10):978-995. PMID: 27834668. (a number of major media reports, including ABC 7, Fierce Biotech, Daily Mail, etc.)
16.Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 2017 Jan 17;18(3):624-635. PMID: 28099842.
17.Nakamura PA, Shimchuk AA, Tang S, Wang Z, Degolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of Retinitis Pigmentosa. eLife 2017 Nov 17; 6. pii: e30577. PMID: 29148976.
18.Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA. Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2016 Nov 1; 57(14):6407-6415. PMID: 27893103. (reported by Foundation Fighting Blindness)
19.Tang S#, Xie M#, Cao N, Ding S. Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery. J Med Chem. 2016 Jan 14; 59(1):2-15. PMID: 26322868. (#equal contribution)
20.Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 6; 7:10080. PMID: 26733021. (a number of major media reports, including Fox News, The Independent, SF Business Times, etc.)
21.Yu C#, Liu K#, Tang S#, Ding S. Chemical approaches to cell reprogramming. Curr Opin Genet Dev. 2014 Oct; 28:50-6. PMID: 25461450. (#equal contribution)
22.Dai Q, Xie X, Xu S, Ma D, Tang S, She X. Total syntheses of Tardioxopiperazine A, Isoechinulin A, and Variecolorin C. Org Lett. 2011 May 6; 13(9):2302-5. PMID: 21456528.
23.Tang S, Xie X, Wang X, He L, Xu K, She X. Concise total syntheses of (+)-strictifolione and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one. J Org Chem. 2010 Dec 3; 75(23):8234-40. PMID: 21067232.
24.Sun Y, Yu B, Wang X, Tang S, She X, Pan X. Stereoselective syntheses of four diastereomers of 3,9,12-trihydroxycalamenene via a benzobicyclo[3.3.1] intermediate. J Org Chem. 2010 Jun 18; 75(12):4224-9. PMID: 20481593.
25.Wang W, Zhang J, He J, Tang S, Wang X, She X, Pan X. Asymmetric total synthesis of (-)-Cladospolide B. Chin J Chem. 2008, 26(6), 1109-1113.
26.Tang S, He J, Sun Y, He L, She X. Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols. J Org Chem. 2010 Mar 19; 75(6):1961-6. PMID: 20151710.
27.He J, Tang S, Tang S, Liu J, Sun Y, Pan X, She X. Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts. Tetrahedron Lett. 2009, 50 (4), 430-433.
28.Tang S, He J, Sun Y, He L, She X. Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles. Org Lett. 2009 Sep 3; 11(17):3982-5. PMID: 19708706. (highlighted by scientific journal SynFacts)