People
WANG Jie
Title：Principal Investigator
Subject：
Email：wang_jie01@gibh.ac.cn
Address：Kaiyuan Dadao 190,510530,Guangzhou,China
Study/Work Experience

2020.12 – now

Guangzhou Institutes of Biomedicine and Health, CAS / Principal Investigator

2014.12 – 2020.11

Johns Hopkins University School of Medicine / Postdoctoral fellow

2009.09 – 2014.07

Shanghai Institutes for Biological Sciences, CAS / Ph.D. in Bioinformatics

2005.09 – 2009.07

Chongqing University Bioengineering College / Bachelor

Research Areas

Wang Lab focuses on epigenomics of diseases and tissue regeneration. The team developed integrative analysis of multi-omics and regulatory network reconstruction, uncovered epigenomic regulations of retinal degeneration and regeneration, and partially realized retinal regeneration in mammals. Wang Lab has published papers in Science, Nature Communications, Briefings in Bioinformatics, and so on. Currently, Dr. Wang was supported by the funding from the National Natural Science Foundation of China and the Ministry of Science and Technology. More details are available from the homepage of Wang Lab https://jiewanglab.github.io/us/index.html.

 



Academic Performance
Dr. Wang is a principal investigator in Guangzhou Institutes of Biomedicine and Health, CAS. Dr. Wang received his Ph.D. in bioinformatics from Shanghai Institutes for Biological Sciences, CAS. Dr. Wang completed postdoctoral training in Johns Hopkins University. Dr. Wang focuses on epigenomics of diseases and tissue regeneration. Dr. Wang developed integrative analysis of multi-omics and regulatory network reconstruction, uncovered epigenomic regulations of retinal degeneration and regeneration, and partially realized retinal regeneration in mammals. Since 2016, Dr. Wang has published papers in Science, Nature Communications, Hepatology, Clinical Cancer Research, and so on.

1. Awarded as an Outstanding Young Scientist by the National Natural Science Foundation of China

2. Awarded as a Young Top Talent of Pearl River Talent Program in Guangdong Province

Representative Papers

1.   Hoang T#,Wang J#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T,Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR*, Qian J*, Blackshaw S*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 2020, 370(6519): eabb8598. #co-first author, *corresponding author.

2.   Wang J#, Zibetti C#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S*, Qian J*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications 2018, 9(1): 1-13.

3.   Jiang J#, Li J#, Huang S, Jiang F, Liang Y, Xu X*, Wang J*. CACIMAR: cross-species analysis of cell identities, markers, regulations, and interactions using single-cell RNA sequencing data. Briefings in Bioinformatics 2024, 25(1): bbae283.

4.   Fu Y#, Jiang F#, Zhang X, Pan Y, Xu R, Liang X, Wu X, Li X, Lin K, Shi R, Zhang X, Ferrandon D, Liu J, Pei D, Wang J*, Wang T*. Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging. Nature Communications 2024, 15(1): 1-21.

5.   Jiang J#, Lyu P#, Li J#, Huang S, Tao J, Blackshaw S, Qian J, Wang J*. IReNA: integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience 2022, 25(11): 105359.