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Jiancun Zhang, Ph.D.
Principal Investigator


Education:
Ph. D., Organic Chemistry, August, 1990, University of Pittsburgh, Pittsburgh, PA 15260, Advisor, Dennis P. Curran
English Language Certificate, May, 1985, Guangzhou English Language Center,  Zhongshan University, Guangzhou, China
B. S., Chemistry, June 1984, Fudan University, Shanghai, China

Experiences:
Principle Investigator
Guangzhou Institute of Biomedicine and Health, 2005, 1 -present
Chief Scientific Officer
Tsinghua Yuanxing Biopharmaceutical Inc. (www.thyx.com), Shenzhen, China, 2001.11-2004, 12
Professor of Chemistry, Shanghai Jiaotong University, 2002-2004.12
Scientist, Senior Scientist and Project Leader, Gilead Sciences, Inc. (www.gilead.com), 344 Lakeside Dr., Foster City, CA 94404, September, 1992, 9-2001, 12
Postdoctoral Research Associate, Duke University, Durham, NC 27706, September, 1990-August, 1992
Teaching Fellow, Research Assistant and Teaching Assistant, University of Pittsburgh, Pittsburgh, PA 15260, September 1985-August, 1990.

Awards:   
Andrew Mellon Predoctoral Fellowship, University of Pittsburgh, 1988-1989
Chemistry Graduate Program Fellowship, Cosponsored by the Education Ministry, PR
China and Professor William Doering of Harvard University, 1984-1990

Membership:
American Chemical Society
Chinese American Chemical Society
Society of Chinese Bioscientists
Silicon Valley Entrepreneur Association

Personnel: 


Research:
Extensive technical experience in organic chemistry, bioorganic chemistry and medicinal chemistry; Expertise in new synthetic method development, medicinal chemistry, new drug design, nucleic acid chemistry and pharmaceutical development; Excellent organizational, supervisory, and communication skills; Extensive experience in rational drug design pharmaceutical and biotechnological products and business development; Extensive management and research experiences in biopharmaceutical industries both in the US and China.

Publications:
1. Peijun Liu, Juan Wang, Jiancun Zhang*, and Fayang G. Qiu* A Concise Total Synthesis of Minfiensine Organic Letters2011 13 (24), 6426-6428
2. Peijun Liu, Kemei Tao, Liwen Zhao, Wang Shen* and Jiancun Zhang* Synthesis of 2-Bromo-1H-indenes via Copper-Catalyzed Intramolecular Cross-Coupling of gem-Dibromoolefins Tetrahedron Letters. 2012, in print
Honggeng Wang, Jiali Zhao, Jiancun Zhang, Qiang Zhu Brønsted Acid-Promoted Sequential Hydroarylation– Hydroamidation of Arene-Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)-quinazolinones Advanced Catalysis, 2011, 353
3. Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Prof. Dr. Jiancun Zhang, Prof. Dr. Qiang Zhu Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles Angewandte Chemie International Edition 2011,50, 5678
4. Yu Zhao, Deyao Li, Liwen Zhao, Jiancun Zhang*A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamidesin PEG-400 Synthesis, 2011, 20, 873
5. Liwen Zhao, Kemei Tao, Haitian Li and Jiancun Zhang* Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines Tetrahedron, 2011, 67, 2803
6. Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang,* and Qiang Zhu* A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines. J. AM. CHEM. SOC. 2010, 132 (38), 13217–13219. (IF=8.580)
7. YIN BIAOLIN; LIU ZHAOGUI; ZHANG JIANCUN; LI ZHENGRONG N,N '-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds Synthesis 2010,19, 991 (IF=2.572)
8. Baishan Jiang, Kemei Tao, Wang Shen,*, Jiancun Zhang,*Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins. Tetrahedron Letters. 2010, 6342. (IF=2.660)
9. Li, Deyao; Zhao, Yu; Ye, Liu; Chen, Chaonan; Zhang, Jiancun. A Formal Total Synthesis of Fostriecin by a Convergent Approach. Synthesis :2010, 19, 3325-3331. (IF=2.572)
10. Zhao Lingli, Jin Changjiang, Chu Youjun, Varghese Chris, Hua Shasha, Yan Feng, Miao Yong, Liu Jing, Mann David, Ding Xia, Zhang Jiancun, Wang Zhiyong, Dou Zhen, Yao Xuebiao*. Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity.Journal of Biological Chemistry, 2010, 285(4): 2488-2497 (IF=5.328)
11. Kemei Tao, Jianlong Zheng, Zhaogui Liu, Wang Shen,* Jiancun Zhang * Facile synthesis of benzoxazoles from 1,1-dibromoethenes. Tetrahedron Letters. 2010, 51, 3246–3249 (IF=2.660)
12. Zhaogui Liu , Deyao Li , Biaolin Yin, Jiancun Zhang*,Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group. Tetrahedron Letters, 2010, 51,240–243(IF=2.660)
13. Yin, Biao-Lin; Liu, Zhao-Gui; Zhang, Jiancun; Li, Zheng-Rong: N, N′-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds Tetrahedron Letters. 2008 49, 3687 (IF=2.572)
14. Liu Ye, Qian Chen,* Jiancun Zhang,*, and Veronique Michelet*, PtCl2-Catalyzed Cycloisomerization of 1,6-Enynes for the Synthesis of Substituted Bicyclo[3.1.0]hexanes. J. Org. Chem. 2009, 74, 9550–9553. (IF=3.952)
15. Wen Lu Liu, Jiancun Zhang*, Fa Qin Jiang, and Lei Fu,Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues. Arch. Pharm. Chem. Life Sci. 2009, 342, 577 – 583(IF=1.429)
16. Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang *, Qiang Zhu *An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas. Tetrahedron Letters,2009, 50, 6841–6843(IF=2.538)
17. Jianlong Zheng, Biaolin Yin, Wenming Huang, Xiaopeng Li, Hequan Yao, Zhaogui Liu, Jiancun Zhang, Sheng Jiang. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth(III) bromide in acetonitrile. Tetrahedron Letters, 2009, 50, 5094–5097(IF=2.538)
18. Kai Yuan, Na Li, Kai Jiang, Tongge Zhu, Yuda Huo, Chong Wang, Jing Lu, Andrew Shaw, Kelwyn Thomas, Jiancun Zhang, David Mann, Jian Liao, Changjiang Jin, and Xuebiao Yao, PinX1 Is a Novel Microtubule-binding Protein Essential for Accurate Chromosome Segregation, Journal of Biological Chemistry, 2009, 284, 23072–23082 (IF=5.52)
19. Biaolin Yin, Zhaogui Liu, Mingjun Yi, and Jiancun Zhang*, A n efficient method for the synthesis of disubstituted thioureas via the reaction of N, N’-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions, Tetrahedron Lett. 2008, 49, 3687 (IF=2.615)
20. Chen Yao, Peng Yingdan, Jiancun Zhang, Lei fu,Syntheses and biological evaluations of novel selenonucleosides, Nucleoside, Nucleotide and Nuclei Acids” 2008, 27, 1001(IF=0.723)
21. YIN Biao-Lin, CHEN Li, XU. Han-hong, ZHANG. Jian-Cun, WU. Yu-Lin, Synthesis and Bio-activities of Pyrazole, Pyridine Substituted Tonghaosu Analogs. Chinese Journal of Chemistry,2007, 25 (06): 808—813 (IF=0.712)
22. J. Zhang,J. Shaw and M. Matteucci “an Oligonucleotide Containing a Pentathymidine 3’-thioformacetal Unit: Synthesis and Binding Studies” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 319.
23. J. Zhang and M. Matteucci “2-Thioquinolines as Masked Sulfhydryls, the development of a Novel Sulfur Protecting group” Tetrahedron Letters, 1999, 40, 1467.
24. J. Zhang and M. Matteucci “Synthesis of a PH-mediated N-Acylsulfamide Linked Dinucleotide and Its Incorporation into an Oligonucleotide” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2213.
25. J. Zhang, T. Terhost and M. Matteucci “Synthesis and Preliminary Hybridization study of a Boranophosphate-linked Oligonucleotide” Tetrahedron Letters, 1997, 38, 4957.
26. J. Zhang and M. Matteucci “a Mild Method for the Synthesis of 3’-Thioformacetal Dinucleotide: the Development of Diphenylphosphinate Acetal as a Glycosylating agents” Tetrahedron Letters, 1995, 36, 8375.
27. M. C. Pirrung, J. Zhang, K. Lackey, D. D. Sternbach and F. Brown “Reactions of a Cyclic Rhodium Carbenoid with Aromatic Compounds and Vinyl ethers” J. Org. Chem., 1995, 60, 2112.
28. M. C. Pirrung, J. Zhang and A. T. Morehead, Jr “Dipolar Cycloaddition of Rhodium Carbenoids to Digonal Carbon. Synthesis of Isoeuparin” Tetrahedron Letters, 1994, 35, 6229.
29. D. P. Curran, W. Shen, J. Zhang, S. V. Geib and C.-H. Lin “Controlling Stereochemistry in Radical addition and Cycloaddition reactions with Oppolzer’s Camphor Sultam” Heterocycles, 1994, 37, 1773.
30. M. C. Pirrung and J. Zhang “Asymmetric Cycloaddition Reactions of Diazocompounds Mediated by a Binaphthophosphate Rhodium Catalyst” Tetrahedron Letters, 1992, 40, 5987.
31. J. Zhang and D. P. Curran “the Cycloadditive Route to syn 1,2-Diols. The Total Syntheses of Brevicomin and (-)-Pestalotin” J. Chem. Soc., Perkin Trans. 1, 1991, 2627.
32. M.C. Pirrung, J. Zhang and A. T. McPhail “Dipolar Cycloadditions of Cyclic Rhodium Carbenoids to Aromatic heterocycles” J. Org. Chem., 1991, 56, 6259.
33. D. P. Curran and J. Zhang “Nucleophilic Addition and reduction of 5-Acyl and 5-Formyl-isoxazolines. A General preparation of syn and anti -dihydroxylcarbonyls” J. Chem. Soc., Perkin Trans. 1, 1991, 2613.
34. D. P. Curran, W. Shen, J. Zhang and T. A. Heffner “Asymmetric Radical Addition, Cycloaddition and Annulation reactions with Oppolzer’s Camphor Sultam” J. Am. Chem. Soc., 1990, 112, 6738.
35. J. Zhang “Nucleosides, Nucleotides and Nucleic Acids” and “Peptides and Proteins” in “Natural Products Synthesis”, Li Shaoshun Ed. 2004, chemistry industry publisher
36. K. Tao, Y. Zhou and J.Zhang “A Practical Synthesis of Fulvoxamine” Chinese Pharmaceutical industry, 2005, 65


Patents:
1. J. Zhang and M. Matteucci “Improved Method for Oligonucleotide Analog Synthesis” US Patent, 5, 646, 269, July 8th, 1997.
2. J Zhang and etc “Cellular accumulation of phosphonate analogs of HIV proteaseinhibitor compounds” US patent, 10/423,496, April 25th, 2003
3. J. Zhang and etc. “Method and compositions for identifying anti-HIV therapeutic compounds” US patent, 10/740,694, Dec. 22, 2003
4. Arimilli, Murty N , Zhang, Jiancun, and etc. Preparation of phosphonate analogs of HIV protease inhibitors and methods for identifying anti-HIV therapeutic compounds. PATENT: WO 2005064008
5. Zhang Jiancun ; Zheng Rongyu, Nanosilver particle coated textiles WO2005038122 2005 -04 -28
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