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Wu’s Laboratory

Xiaoxing Wu, Ph.D.
Principal Investigator

Dr. Wu was born and raised in Huangshan, Anhui Province. He obtained his B.S. degree from Lanzhou University and M.S. degree from Zhejiang University with Prof. Yan-Guang Wang. In the fall of 2004, he joined in the research group of Prof. Barry B. Snider at Brandeis University (Waltham, USA), where he completed his Ph.D. study. During 2009-2011, he did the post-doctoral research in Prof. Stephen L. Buchwald's laboratory at Massachusetts Institutes of Technology (Cambridge, USA). Dr. Wu was appointed as a Principle Investigator in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences in Oct. 2011. He has long been engaged in the research on organic synthesis and organometallics.


Dr. Wu’s research is focused on three main areas: (1) Total synthesis of complex natural products and analogues with promising biological profiles; (2) Transition metal-catalyzed method development for umpolung reactivity-oriented reactions; (3) Drug discovery based on our synthesized small molecule agents.

1. Wu, X.; Fors, B. P.; Buchwald, S. L.* “A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols” Angew. Chem. Int. Ed. 2011, 50, 9943-9947.
2. Cai, X.-C.; Wu, X.; Snider, B. B.* “Synthesis of the Spiroiminal Moiety of Marineosins A and B” Org. Lett. 2010, 12, 1600-1603.
3. Wu, X.; Zhou, J.; Snider, B. B.* “Introduction of the ()-Berkelic Acid Side Chain and Assignment of the C-22 Stereochemistry” J. Org. Chem. 2009, 74, 6245-6252.
4. Wu, X.; Zhou, J.; Snider, B. B.* “Synthesis of ()-Berkelic Acid” Angew. Chem. Int. Ed. 2009, 48, 1283-1286. (Highlighted in Synfacts 2009, 825; described as one of the top eleven “Amazing Chemicals Invented by Nature, Rebuilt in Lab” in the magazine Wired in Jan. 2009.)
5. Snider, B. B.*; Wu, X. “Synthesis of ()-Chaetominine” Org. Lett. 2007, 9, 4913-4915. (Highlighted in Synfacts 2008, 335; recognized as one of the Most-Accessed Articles for the fourth-quarter of 2007.)
6. Snider, B. B.*; Wu, X.; Nakamura, S.; Hashimoto, S. “A Short, Formal, Biomimetic Synthesis of (±)-Polygalolides A and B” Org. Lett. 2007, 9, 873-874. (Highlighted in Synfacts 2007, 788.)
7. Snider, B. B.*; Wu, X. “Synthesis of (+)-Myrtopsine, (+)-7,8-Dimethoxymyrtopsine, and Related 2,3-Dihydro-3-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran Natural Products” Heterocycles 2006, 70, 279-294. (Special issue to Prof. Weinreb.)
8. Wang, Y.-G.*; Wu, X.-X.; Jiang, Z.-Y. “A Mild and Efficient Selective Tetrahydropyranylation of Primary Alcohols and Deprotection of THP Ethers of Phenols and Alcohols Using PdCl2(CH3CN)2 as Catalyst” Tetrahedron Lett. 2004, 45, 2973-2976.

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