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Laboratory of Natural Product Synthesis

Fayang Qiu, Ph.D.
Principal Investigator, Head of the Laboratory of Natural Product Synthesis.

Dr. Fayang Qiu is a synthetic organic chemist. He obtained a Bachelor’s degree in chemistry from Wuhan University in 1982, and a Master’s degree from Shanghai Institute of Organic Chemistry in 1987. Following a Ph.D. degree from the Ohio State University in 1996, he pursued postdoctoral training at the same university and then the University of California at Berkeley. He worked for the development of new technologies to enhance the oral bioavailability of pharmaceuticals in Biotech companies at California for about eight years. He also worked at the School of Pharmacy at the University of Mississippi as a Visiting Scholar before joining GIBH in 2007.


The strategy of his research group is to do drug discovery based on the total syntheses of natural products. Briefly, they choose an important natural product as the target and perform its total synthesis, which requires an efficient synthetic strategy. After completion of the total synthesis, they begin to synthesize the analogs and build a small compound library before performing the biological studies, the results of which will provide a guideline for chemists to further optimize the structures of the drug candidates.

Medicinal Chemistry:
Efficient synthesis and rapid optimization of epothilones for the treatment of cancers; Rapid synthesis and structural modification of norzoanthamine.

Organic Chemistry:
Efficient synthesis of a variety of medicinally important alkaloids, terpenes and marine natural products; Development of New Synthetic Methodologies and Theories of Organic Chemistry.

Process Development:
Synthesis of Cefocelis sulfate.

Recently Completed Total Syntheses:

1. Heping Ye, Gang Deng, Jun Liu and Fayang G. Qiu, Expedient Construction of the Ziegler Intermediate Useful for the Synthesis of Forskolin via Consecutive Rearrangements, Org. Lett., 2009, 11, 5442-5444.
2. Fayang Qiu, Strategic Efficiency, the New Thrust for Synthetic Organic Chemists, Can. J. Chem. 2008, 86, 903-906.

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