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Jiang's Laboratory

Sheng Jiang , Ph.D
Principal Investigator

2000-2003, Ph.D., Shanghai Institute of Organic Chemistry,CAS China. 2003-2007, Postdoctoral Fellow, Laboratory of Medicinal Chemistry, National Cancer Institute, NIH.
2007 –Present, Guangzhou Institute of Biomedicine and Health, CAS


1)Total Synthesis and Molecular Diversity of Histone Deacetylase Inhibitor-Largazole

2) Total Synthesis and Structure Activity Analysis of Protease Inhibitor Argyrin A

1. Q. Xiao, Y. Liu, Y. Qiu, G. Zhou, C. Mao, Z. Li, Z.-J. Yao*, S. Jiang*. Potent Antitumor Mimetics of Annonaceous Acetogenins Embedded with an Aromatic Moiety in the Left Hydrocarbon Chain Part; J. Med. Chem. 2011, 54, 525-533.
2. K. Yang, Y. Qiu, Z. Li, Z. Wang, S. Jiang*, Ligands for Copper-Catalyzed C- N Bond Forming Reactions with 1 Mol% CuBr as Catalyst. J. Org. Chem, 2011, 76, 3151-3159.
3. Y. Qiu, Y. Liu, K. Yang, W. Hong, Z. Li, Z. Wang, S. Jiang*. New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes. Org. Letters, 2011, 13, 3556-3559.
4. K. Yang, Z. Li, Z. Wang, S. Jiang*. Highly Efficient Synthesis of Phenols by Copper-Catalyzed Hydroxylation of Aryl Iodides, Bromides, and Chlorides. Org. Letters, 2011, 13, 4340-4343.
5. W. Wu, Z. Li, G. Zhou, S. Jiang*. Total synthesis of argyrins A and E. Tetrahedron. Lett. 2011, 52, 2488-2491.
6. Q. Xiao, Y. Liu, Y. Qiu, Z. Yao, G. Zhou, Z.-J. Yao*, S. Jiang*. Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities. Bioorg. Med. Chem. Lett. 2011, 21, 3613-3615.
7. S. Li, H. Yao, J. Xu*, S. Jiang*. Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors. Molecules, 2011, 16, 4681-4694.
8. L. Johannessen, J. Remsberg, V. Gaponenko, K. M. Adams, J. J. Barchi, S. G. Tarasov, S. Jiang, N. I. Tarasova. Peptide Structure Stabilization by Membrane Anchoring and its General Applicability to the Development of Potent Cell-Permeable Inhibitors. ChemBioChem. 2011, 12, 914-921
9. W. Hong, Y. Qiu, Z. Yao, Z. Wang, S. Jiang*. Palladium-Catalyzed Direct C–H Arylation of Unactivated Arenes with Aryl Halides. Tetrahedron. Lett. 2011, 52, 4916-4919.
10. X. Zeng, W. Huang, Y. Qiu, S. Jiang*. Efficient Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia. Organic & Biomolecular Chemistry. 2011, 9, 8224-8227.
11. X. Zeng, B. Yin, Z. Hu, C. Liao, Z. Li, G. Zhou*, S. Jiang*.Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells. Orgainc. Lett. 2010, 12, 1368-1371.
12. J. Zheng, B. Yin, W. Huang, X. Li, H. Yao, Z. Liu, S. Jiang*. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth (III) bromide in acetonitrile. Tetrahedron. Lett. 2009, 50, 5094-5097
13. S. Jiang*,C. Liao, L. Bindu, B. Yin, K. W. Worthy, R. J. Fisher, T. R. Burke, Jr., M. C. Nicklaus, P. P. Roller. Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg. Med. Chem. Lett.2009, 19, 2693-2698.
14. S. Jiang*, Z. Li, K. Ding, P. P. Roller. Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization. Current Organic Chemistry. 2008, 12, 1502-1542.
15. Z. Nikolovska-Coleska, J. Meagher, S. Jiang, S. A. Kawamoto,W. Gao, H. Yi, D. Qin, P. P. Roller, J. Stuckey, S. Wang. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains. Anal Biochem. 2008, 374, 87-98.
16. O. A. Timofeeva, V. Gaponenko, S. J. Lockett, S. G. Tarasov, S. Jiang, C. J. Michejda, A. O. Perantoni, N. I. Tarasova. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS Chem Biol. 2007, 2, 799-809.
17. S. Jiang, P. Li,S. L. Lee, C. Y. Lin, Y.Q Long, M. D. Johnson, R. B. Dickson, P. P. Roller. Design and Synthesis of redox stable analogues of Sunflower Trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of Matriptase.Orgainc. Lett. 2007, 9, 9-12.
18. P. Li, S. Jiang, P. C. Stephanie, O. Lyn, D. N. Krag, P. P. Roller. Design and Synthesis of Water-Soluble Conjugates of Paclitaxel to Extracellular Doma in of ErbB2-Recognizing Peptide. Biopolymers.2007, 87, 225-230.
19. H. Sun, Z. Nikolovska-Coleska, J. Lu, J. Meagher, C. Yang, S. Qiu, Y. Tomita, Y. Ueda, S. Jiang, Krajewski, P. P. Roller, J. A. Stuckey, S.Wang.
20. Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domainsin XIAP. J. Am. Chem. Soc. 2007, 129, 15279-15294
21. S. Jiang, P. Li, C. C. Lai, J.A. Kelley, P. Roller. Design and Practical Synthesis of Fully Protected analogs of L-γ-Carboxyglutamic Acid. J. Org. Chem. 2006, 71, 7307-7314.
22. S. Jiang, P. Li, M. Peach, R. J. Fisher, T. R. Burke, M. Nicklaus, P. P. Roller. Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. Biochem. Biophys. Res. Commun. 2006, 349, 497-503.
23. S. Jiang, Y. Li, X. G. Chen, T. S. Hu, Y. L. Wu, Z.-J. Yao. Parallel fragment assembly strategy towards multiple-ether mimicry of anticancer annonaceous acetogenins. Angew. Chem. Int. Ed. 2004, 43, 329-334.
24. G. R. Huang, S. Jiang, Y. L. Wu, Z. J. Yao, J.R. Wu. Induction of cell death of gastric cancer cells by a modified compound of the annonaceous acetogenin family. Chem Bio.Chem 2003, 4, 1216-1221.
25. S. Jiang, Z. Liu, G. Sheng, B. B. Zeng, X. G. Cheng, Y.L. Wu, Z.J. Yao. Mimicking of Annonaceous Acetogenins: Enantionselective Synthesis of a (4R)-Hydroxy Analog Having Potent Antitumor Activity. J. Org. Chem, 2002, 67, 3404-3408.

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