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PPublications with members of the DDP as authors

*DDP member is either first/last author on the paper or twoDDP members or more are co-authors on the paper.

1. Xiaomei Ren, Qiang He, Lei Duan, Zhang Zhang, Yi Zhou, Donghai Wu, Jingxuan Pan, Duanqing Pei and Ke Ding. Identification of a New Small-Molecule Inhibitor of STAT3 Signaling Pathway. ACS Med. Chem. Lett. 2010, 1 (9), 454–459.

2. Xiaoyun Lu, Qian Cai and Ke Ding. Recent Developments in the Third Generation Inhibitors of Bcr-Abl for Overriding T315I mutation, Current Medicinal Chemistry, 2011: 18(14):2146-57.

3. Deping Wang, Zhang Zhang, Xiaoyun Lu, Yubing Feng, Kun Luo, Jirong Gan, Yingxue Liu, Junting Lu, Xiang Li, Fengxiang Zhang, Zhengchao Tu, Qian Cai, Xiaomei Ren, Ke Ding. Hybrid Compounds as New Bcl/Abl Inhibitors. Bioorg.Med.Chem.Lett,2011,21(7), 1965-1968.

4. Jing Xu, Hao Wang, Tao Liang, Xiangsheng Cai, Xiurong Rao, Zhenbo Huang, Guoqing Sheng. Retinoic acid promotes neural conversion of mouse embryonicstem cells in adherent monoculture. Mol Biol Rep DOI 10.1007/s 11033-011-0800-8.

5. Jing Xu, Hao Wang1, Tao Liang, XiangSheng Cai1, XiuRong Rao, ZhenBo Huang& GuoQing Sheng. In vitro induction of mouse meningeal-derived ips cells into neural-like cells. Physical Chemistry chinese Science Bulletin. January 2011 Vol.56 No.1: 1–6.

6. Xiujie Liu, Xiaoli Huang, Dongye Wang, Yanyan Diao, Honglin Li, Xiaoyan Hui, Yi Wang, Aimin Xu, Dnonghai Wu, Ke Ding. New Aromatic Substituted Pyrazoles as Selective Inhibitors of Human Adipocyte Fatty Acid-Binding Protein. Bioorganic & Medicinal Chemistry Letters, 2011, 21, 2949-2952.

7. Cheng H, Wan J, Lin MI, Liu Y, Lu X, Liu J, Xu Y, Chen J, Tu Z, Cheng YS, Ding K. Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein.J Med Chem. 2012 Mar 8; 55(5):2144-53. Epub 2012 Feb 27.

8. Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA. Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Hum Mol Genet. 2011 Aug 15; 20(16):3176-87. Epub 2011 May 18.

9. Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MD. Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci. 2011 Apr; 20(4):735-44. doi: 10.1002/pro.606.

10. Shaohua Chang, Zhang Zhang, Xiaoxi Zhuang, Honglin Li, Zhengtao Tu, Xiaomei Ren, Ke Ding. New thiazole carboxamides as potent inhibitors of Akt Kinases. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 1208-1212.

11. Huimin Cheng, Junting Wan, Meng-I Lin, Yingxue Liu, Xiaoyun, Lu, Jinsong Liu, Yong Xu Jianxin Chen, Zhengchao Tu, Yih-Shyun E. Cheng, and Ke Ding , Design, synthesis and in vitro biological evaluation of 1H-1, 2, 3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein. J. Med. Chem. 2012, 55 (5), pp 2144–2153.

12. Shaohua Chang, Lianwen Zhang, Shilin Xu, Jinfeng Luo, Xiaoyun Lu, Zhang Zhang, Tianfeng Xu, Yingxue Liu, Zhengchao Tu, Yong Xu, Xiaomei Ren, Meiyu Geng, Jian Ding, Duanqing Pei, Ke Ding. Design, Synthesis and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor T790M mutant. J. Med. Chem. 2012, DOI: 10.1021/jm201591k.

13. Cheng H, Wan J, Lin MI, Liu Y, Lu X, Liu J, Xu Y, Chen J, Tu Z, Cheng YS, Ding K. Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein.J Med Chem. 2012 Mar 8; 55(5):2144-53. Epub 2012 Feb 27.

14. Xiaoyun Lu*, Lijie Peng, Man Lv and Ke ding*. Recent Advance in the Design of Small Molecular Modulators of Estrogen-Related Receptors. Current Pharmaceutical Design, 2012, 18, 3421-3431.

15. Xiaoyun Lu a,b, Xiaobo Liu a, Baojie Wan c, Scott G. Franzblau c, Lili Chen d, Changlin Zhou d, Qidong You a,*. Synthesis and evaluation of anti-tubercular and antibacterial activities of new4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives.Part 2. European Journal of Medicinal Chemistry 49 (2012) 164-171.

16. Xiaoyun Lu 1,2,*, Man Lv 1, Kun Huang 2, Ke Ding 1 and Qidong You 2. Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors. Int. J. Mol. Sci. 2012, 13, 6620-6638; doi: 10.3390/ijms13066620.

17. Aksoy I. *, Jauch R. *(* shared first author), Eras V., Bin AC., Chen J., Divakar U., Ng CK., Kolatkar PR., Stanton LW. (2013) Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming. Stem Cells 20 Aug [Epub]

18. Sun, W., Hu, X., Lim, M.K., Ng, C.K., Choo, S.H., Kolatkar, P.R., Jauch, R. (corresponding author) and Prabhakar, S. (2013) Estimating protein-DNA binding energies from in vivo binding profiles. Nucl Acids Res, 2013 Apr 16

19. Jankowski, A., Szczurek, E., Jauch R., Tiuryn, J., Prabhakar, S.(2013) Comprehensive Prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimmers. Genome Research, 2013 Apr 3 Epub

20. Xin Zhao, Yanling Jie, Matthew R. Rosenberg, Junting Wan, Shaogao Zeng, Wei Cui,Yiping Xiao, Zhiyuan Li, Zhengchao Tu, Marco G. Casarotto,, Wenhui Hu.Design and synthesis of pinanamine derivatives as anti-influenza AM2 ion channel inhibitors.Antiviral Res. 2012 Nov;96(2):91-9. doi: 10.1016/j.antiviral.2012.09.001. Epub 2012 Sep 13.

21. Hui Xie, Lili Zeng, Shaogao Zeng, Xin Lu, Guicheng Zhang, Xin Zhao, Na Cheng, Zhengchao Tu,Zhiyuan Li, Hongjiang Xu, Ling Yang, Xiquan Zhang, Min Huang, Junling Zhao, Wenhui Hu.Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.Eur J Med Chem. 2012 Jun;52:205-12. doi: 10.1016/j.ejmech.2012.03.015. Epub 2012 Mar 17.

22. Yupeng Li, Mengjie Shen, Zhang Zhang, Jinfeng Luo, Xiaofen Pan, Xiaoyun Lu, Huoyou Long, Donghai Wen, Fengxiang Zhang, Fang Leng, Yingjun Li, Zhengchao Tu, Xiaomei Ren, and Ke Ding. Synthesis, and Biological Evaluation of 3-(1H-1,2,3-Triazol-1-yl)benzamide Derivatives as Potent Pan Bcr-Abl Inhibitors Including the Threonine315→Isoleucine315 Mutant.J Med Chem. 2012 Nov 26;55(22):10033-46. doi: 10.1021/jm301188x. Epub 2012 Nov 1.

23. Tianfeng Xu, Lianwen Zhang, Shilin Xu, Chao-Yie Yang, Jinfeng Luo,Fang Ding, Xiaoyun Lu, Yingxue Liu, Zhengchao Tu, Shiliang Li, Duanqing Pei, Qian Cai, Honglin Li, Xiaomei Ren, Shaomeng Wang, and Ke Ding. Tricyclic Pyrimidines as Selective Inhibitors of EGFR Threonine790 →Methionine790 (T790M) Mutants.Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8387-90. doi: 10.1002/anie.201302313. Epub 2013 Jun 26.

24. Shaogao Zeng, Hui Xie, , Li-li Zeng, Xin Lu, Xin Zhao, Gui-cheng Zhang, Zheng-chao Tu,Hong-jiang Xu, Ling Yang, Xi-quan Zhang, Wenhui Hu. Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.Bioorg Med Chem. 2013 Apr 1;21(7):1749-55. doi: 10.1016/j.bmc.2013.01.062. Epub 2013 Feb 8.

25. Hui Xie, Lili Zeng, Shaogao Zeng, Xin Lu, Xin Zhao, Guicheng Zhang,Zhengchao Tu, Hongjiang Xu, Ling Yang, Xiquan Zhang, Shanchun Wang,Wenhui Hu. Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization.EurJ Med Chem. 2013 Aug 13;68C:312-320.doi:10.1016/j.ejmech.2013.08.010.

26. Xu, Shilin; Zhuang, Xiaoxi ; Pan, Xiaofen ; Zhang, Zhang ; Duan, Lei; Liu, Yingxue ; Zhang, Lianwen ; Ren, Xiaomei; Ding, Ke. 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor á.J Med Chem. 2013 Jun 13;56(11):4631-40. doi: 10.1021/jm4003928. Epub 2013 May 24.

27. Mingshan Gao , Lei Duan , Jinfeng Luo , Lianwen Zhang , Xiaoyun Lu , Yan Zhang , Zhang Zhang , Zhengchao Tu, Yong Xu , Xiaomei Ren , and Ke Ding. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a] pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors.J Med Chem. 2013 Apr 25;56(8):3281-95. doi: 10.1021/jm301824k. Epub 2013 Apr 10.

28. Xiaomei Ren, Xiaofen Pan, Zhang Zhang, Deping Wang, Xiaoyun Lu, Yupeng Li, Donghai Wen, Huoyou Long, Jinfeng Luo, Yubing Feng, Xiaoxi Zhuang, Fengxiang Zhang, Jianqi Liu, Fang Leng, Xingfen Lang, Yang Bai, Miaoqin She, Zhengchao Tu, Jingxuan Pan, and Ke Ding *. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Bcr-Abl and overcomes clinically acquired mutation-induced resistance against imatinib.J Med Chem. 2013 Feb 14; 56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28.

29. John J Talley, Wei-Xing Dan, Jianqi Liu, Micky D. Tortorella, Zhengchao Tu and YanmeiZhang.Palladium-Catalyzed Synthesis of Trimethylsilyl Substituted BenzopyranDerivatives. The Open Organic Chemistry Journal, 2013, 7, 000-000.


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